The present study used hierarchical linear modeling to examine correlates of benefit finding at study entry and individuals trajectories of benefit finding over time among men treated for early stage prostate cancer (n = 261). Correlates associated with benefit finding at study entry included intrinsic religiosity, perceived social support, perceived present control, approach coping, use of emotional support, avoidant coping, and religious coping. Within-persons changes in optimism, perceived social support, perceived present control, approach coping, use of emotional support, avoidant coping, and religious coping were associated with within-persons changes in benefit finding. The association between the trajectories of perceived social support and benefit finding was partially mediated by approach coping and use of emotional support. The findings suggest that coping responses may represent an important mechanism through which changes in benefit finding occur.
A growing body of literature points to positivecontributions made by the cancer experience (benefitfinding), such as an improvement in personalresources and skills, an enhanced sense of purpose, apositive adjustment in life priorities, and closerrelationships. This study explored multiple aspectsof the relationships between intrapersonal andinterpersonal coping skills reported afterparticipating in a group-based cognitive-behavioralstress management intervention or a one-day seminar,levels of social functioning reported at 3- and9-month follow-ups. and reports of benefit findingmeasured at 3- and 9-month follow-ups. Participants,136 women newly treated for stage 0-II breast cancer,were randomized to either the intervention or thecontrol group, and were initially assessedapproximately 4-8 weeks after breast cancer surgery(T1), then at the end of the intervention (T2), thenat 3-month follow-up (T3), and again after a 9-monthfollow-up (T4). Skill building was operationalized asthe difference between T1 and T2 coping skillsscores. The study examined which of these variablesmay have contributed to the report of benefit findingat T3.
Prostate Cancer is an important public issue around the world. In New Zealand alone it is the most commonly diagnosed cancer and the second highest cause of male death. This Heideggerian study aims to offer a deeper understanding of the meaning men attach to this experience and the effects of the diagnosis and treatments in a man being-in-the-world. Using a hermeneutic existential phenomenological approach to research, four themes were found: Disappointment, Being-a-man, Sense of Control, and Life-threatening Disease. The outcomes of this study suggest implications for health professionals in promoting existential care for men.
This book looks at the histologic outcomes of the commonly seen cryotherapy-ineligible lesions in the Cervical Cancer Prevention Progam in Zambia. The need to know what kind of abnormal cervicography requires to have histologic valuation is vital , particularly in he the low economic situations. Sending all abnormal lesions for histology is costly, leads to over treatment and does not reduce the incidence of cervical cancer. Conversely, using a very stringent criteria to send abnormal lesions for histology may lead to inadvertent missing of cancer cases. An accurate criteria for determining which lesions are cryotherapy-ineligible, and therefore requiring histological examination cannot be overemphasised.
The work mainly concerns about computational molecular docking techniques, which can be used for the study of complexes between drug and biomacromolecule (protein). characterizations of such interactions lead to the understanding of the biological function of biomacromolecules and therapeutic effect of drugs, therefore, interest of many laboratories is focused on such study. In this work, I present application of molecular modeling, docking and ADMET techniques to screen potential of dimethylthiohydantoin derivatives as an androgen antagonist. Also, the compare between the title compounds and hydroxyflutamide in prostate cancer treatment has been achieved. The result shows that all the title compounds can possibly act as new leads for the treatment of prostate cancer as they possess androgen antagonist activity. These results may be used in future experiments to investigate the interactions of dimethylthiohydantoin derivatives with the androgen receptor, or may be used in vivo experiments to test their effects on the abilities of treatment of prostate cancer.
Following the international success of Your Life in Your Hands, the groundbreaking book on breast cancer, Professor Jane Plant explains how her diet and lifestyle plan can be used to combat prostate cancer. This revised and updated edition includes new information to help those with other types of cancer, such as colorectal cancer and testicular cancer. In this groundbreaking book, Professor Plant illuminates the relationship between cancer and diet. The book explains the science behind the 'no dairy' diet and then gives useful advice on diet and lifestyle to maximise your health and avoid contracting cancer. For sufferers, their families and anyone who is concerned about the risk of cancer, this book is essential.
The incidence of prostate cancer has been steadily rising for the last 40 years, and it is continuing to rise as life expectancy increases with improved living conditions across the developing countries. Prostate cancer progression and its ability to respond to hormonal therapy is determined by the status of androgen receptor expression.The expression of these receptors are associated with prognostic factors of prostate cancer like Gleason scores. This book provides vital information about the androgen receptor expression and Gleason score, age of the patient, and prostate specific antigen (PSA) values for use by the clinicians to determine the prognosis of this cancer. It is therefore a must read book for; pathologists, urologists, post-graduate students, researchers and other clinicians especially in resource restrained countries.
This was the first study to use salivary cortisol as a biological measure of physiological stress in men treated with localized prostate cancer and to examine the associations with perceived stress, symptoms, symptom distress, and symptom self-management in patients with localized prostate cancer. Cortisol was excreted in a circadian rhythm with heightened activity in the early morning, decreased activity during the day, and lower activity late in the day. Perceived stress was positively correlated with salivary cortisol concentration. Symptoms were correlated with symptom related distress. Frequency of symptoms was associated with symptom self-management strategies for urinary, bowel , and sexual problems. The most effective strategies were: pads and Kegel exercise for managing urinary problems, rest and endurance for bowel symptoms, and expressing feelings and finding alternative ways to express affection for management of sexual dysfunction. Findings provide information on effective strategies that prostate cancer patients found to reduce their symptoms. The strategies used provide a foundation for developing and testing interventions for personalized symptom management.
This book was written to have an idea about prostate specific antigen and its role in diagnosis of prostate cancer which is a common cancer in men.and one of the main leading cancer death allover the world. Prostate cancer is one of the treatable cancers, if diagnosed early. Prostate specific antigen is one of ideal tumor markers for early diagnosis motoring prostate cancer, although it is not specific, but the isoforms of this markers are now used to increase the diagnostic utility of this marker.
This book is the result of sustained hard work by authors to striking results. Readers will definitely get benefit from this book and they can even reproduce the work if they wish to. This book shows association of two carcinogen detoxifying genes (GSTM1 and GSTT1) with prostate cancer risk in Pakistani men. Multiplex PCR was used and striking results have been obtained by revealing the gel on UV light in gel documentation system. It is worth reading this book.
Cancer is a class of diseases in which a group of cells display uncontrolled growth, invasion, and sometimes metastasis.. Prostate cancer is a form of cancer that develops in the prostate, a gland in the male reproductive system. Most prostate cancers are slow growing. However, there are cases of aggressive prostate cancers. The cancer cells may metastasize from the prostate to other parts of the body, particularly the bones and lymph nodes. Loss of PTEN and concomitant activation of AKT could act in partnership with the TMPRSS2-ERG fusion protein to promote progression to prostate cancer through downstream pathways that increase the selective advantage of pre malignant prostatic intraepithelial neoplasia cells.
Prostate cancer, presents a high incidence worldwide and represents the second cause of cancer related deaths in men, after lung cancer. At present, the only noninvasive procedure used for prostate cancer early diagnosis is the measurement of serum prostate-specific antigen in blood. Since its introduction in 1982, it has been demonstrated that the mortality due to prostate cancer has been reduced. But, recently the use of serum PSA has been questioned because it has a low accuracy, especially regarding the specificity. In prostate cancer, new noninvasive diagnostic approaches are needed to replace the standard techniques. Molecular biomarkers has been demonstrated that play an important role in the diagnostic of some cancer types such as lung cancer, colon cancer, bladder cancer, and breast cancer and prostate cancer. Recently, a number of studies have shown the usefulness of molecular biomarkers in the early diagnosis and recurrence prediction in prostate cancer patients.
Cancer is becoming one of the most devastating diseases in the world. Reports from the International Agency for Research on Cancer predict that the global cancer rates will increase 50 percent by 2020. In western countries prostate cancer is the most common cancer in males. To reduce the suffering and death due to cancer is now one of the biggest challenges ever. About 60% of cancer patients receive radiotherapy as part of their disease management. Three dimensional conformal radiation therapy (3D-CRT) and intensity modulated radiation therapy (IMRT) are being used successfully for both the palliative and curative treatments of cancer. The main aim of curative radiotherapy is to deliver a dose of radiation that is high enough to destroy the tumor cells while at the same time minimizing the damage to normal healthy tissues. Radiobiological parameters are used to evaluate and predict the outcome of a treatment plan. In this book, 3D-CRT and IMRT treatment plans for a prostate cancer patient are compared by using a radiobiological model.
Prostate Cancer is the most common malignancy in elderly men. The median age at diagnosis is 68years and the disease incidence escalates sharply with increasing age. The natural history is still relatively unknown and many aspects of progression are poorly understood .Clinically localized disease varies from lower-grade tumors having a more indolent course to high-grade lesions that progress to metastatic disease with relative rapidity. Prostate cancer is most treatable and curable if caught in the earliest stage of the disease. Staging is an important part of developing the best treatment. Choosing a treatment option involves the patient, his family, and one or more doctors. It needs multidisciplinary oncology doctors of prostate cancer specialists as an urologist, a radiation oncologist, and a medical oncologist. The optimal management of prostate cancer that is clinically confined to the prostate remains controversial. Standard treatment options for localized disease include Radical prostatectomy, Radiation Therapy and watchful waiting management.For metastatic prostate cancer it becomes far harder for complete cure.
Prostate Cancer is the second most common cancer that affect men after lung cancer. The cause of prostate cancer is largely unknown but the risk of developing it increases after the ages of 50 and 40 years among Whites and Blacks respectively. Prostate cancer develops very slowly, takes several years to manifest and often spreads to other parts of the body with very low cure rates by the time of diagnosis. Actually, most men die with this cancer and not of it. The survival rate of prostate cancer is between 5 and 10 years for all stages of the disease. Early detection of prostate cancer before it becomes clinically significant, markedly improves cure rates. Two screenings for prostate cancer; Digital Rectal Exam (DRE) and Prostate Specific Antigen (PSA)test are recommended annually for men 40 years and older for early detection and prevention of prostate cancer. Diet low in fat, high in vegetables and fruits, avoiding excessive meat eating and alcohol abuse may reduce a man's risk of prostate cancer. Your health care provider can give you more information about prostate screening and prevention of prostate cancer.
These study explores on the relationship between Polymorphisms of glutathione-S-transferase M1, T1 which is a family of cytosolic enzymes involved in the detoxification of various exogenous as well as endogenous reactive species and the risk of prostate cancer in the Iraqi patients.The present study was included 35 Iraqi men who were diagnosed as prostate cancer patients. the age of the patient ranged from 40 to 86 years. and 25 Apparently healthy men, blood sample were collected Frome the Gazhi Alhariri hospital(in Baghdad),during the period from November, 2012 to may,2013.blood group, Age, family history, smoking were analyzed to observe any relationship between theme and prostate cancer to taken in account as risk factors.